Fig. 6From: Protein nanoparticles directed cancer imaging and therapySchematic representation of the mechanism by which Luc-linker@HFn is recognized by the transferrin receptor and carries out bioluminescence. Luc-linker@HFn is internalized by cancer cells through TfR1. Intracellular GSH can break the disulfide bond and release free luciferin. Luciferin is able to react with luciferase and perform bioluminescence imaging [173]Back to article page