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Fig. 6 | Nano Convergence

Fig. 6

From: Protein nanoparticles directed cancer imaging and therapy

Fig. 6

Schematic representation of the mechanism by which Luc-linker@HFn is recognized by the transferrin receptor and carries out bioluminescence. Luc-linker@HFn is internalized by cancer cells through TfR1. Intracellular GSH can break the disulfide bond and release free luciferin. Luciferin is able to react with luciferase and perform bioluminescence imaging [173]

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