Fig. 4
From: Highly sensitive ultrasound detection using nanofabricated polymer micro-ring resonators
(Reproduced with permission from [32])
a A schematic illustration of the multimodality microscopy system combining laser-scanning confocal microscopy and PAM with the optically transparent polymer MRR. b Line spread function (LSF) calculated by the gradient of the edge spread function of the carbon black thin film target. The lateral resolution of 0.73 μm is determined by the full width at half maximum of the LSF. c Contrast-to-noise ratio (CNR) profile. Estimated axial resolution of 2.12 μm by a shift-and-sum method. d An overlaid image of the flat mount RPE tissue sample from three image modalities: MAP of PAM image, actin-stained fluorescent confocal image, and autofluorescence confocal image of lipofuscin. Three modalities acquired simultaneously. Scale bar 10 μm