Fig. 7
From: Microneedle-mediated nanomedicine to enhance therapeutic and diagnostic efficacy
Copyright 2022, Wiley–VCH GmbH. b. Schematic of fabrication of microneedle structures using the photolithography method with a mixture of two photoresists (PEGDA and DAROCUR), a silicone vessel, a hard sheet of plastic-like acetate (PEN Q38), and a photomask, initiated by casting. Reproduced with permission [153]. Copyright 2015, CC-BY. c. SEM image of a TPP fabricated microneedle structure with open microfluidic channels. Adapted with permission [155]. Copyright 2017, Springer Nature. d. Fabrication process of silicon hollow microneedle arrays, followed by backside hole etching and frontside pillar etching. Adapted with permission [156]. Copyright 2019, Springer Nature. e. Schematic of microneedle fabrication using the DAB method with key steps including droplet dispensing, contact, length control, and air blowing. Adapted with permission [157]. Copyright 2013, Elsevier
Methods for fabrication of microneedle structures. a. Manufacturing process of microneedle patches using the micromolding method, including pouring, vacuum, drying, and demold. Reproduced with permission [152].