Synthetic nanowire/nanotube-based solid substrates for controlled cell growth

Baik, Ku Youn; Park, Sung Young; Namgung, Seon; Kim, Daesan; Cho, Dong-guk; Lee, Minju; Hong, Seunghun

doi:10.1186/s40580-014-0028-0

Nano Convergence

Table 1 Overview of properties of synthetic nanowires/nanotubes

From: Synthetic nanowire/nanotube-based solid substrates for controlled cell growth

	Materials	Diameter	Controllability	Biomedical applications
Polymer nanofibers	Poly (e-caprolactone) (PCL)	0.01 ~ 100 μm	Diameter	Controlled cell growth (adhesion, migration, proliferation, differentiation) [14]–[22]
	Polyaniline (PANi)		Structure (aligned, random)
	Poly (L-lactic acid) (PLLA)		Surface functionalization
	Polyethersulfone (PES)		Degradation
	Poly (D,L-lactide-co-glycolide) (PLGA)		Elasticity
	Poly (D,L-lactide-co-glycolide) (PLGA)		Composition
Carbon-based nanostructures	Signle wall carbon nanotube (swCNT) multi wall carbon nanotube (mwCNT)	1 ~ 2/2 ~ 100 nm	Diameter	Controlled cell growth (adhesion, migration, proliferation, differentiation) [26]–[36]
			Structure (aligned, random, vertical)
			Surface functionalization
	Carbon nanofiber (CNF)	3.5 ~ 500 nm	Surface functionalization	Controlled cell growth (adhesion, migration, proliferation, differentiation) [39]–[41]
Inorganic nanowires/nanotubes	TiO₂ nanotube	10 ~ 100 nm	Diameter	Controlled cell growth (adhesion, proliferation, differentiation) [46]–[48]
	TiO₂ nanotube	10 ~ 100 nm	Diameter	Orthopaedic implant [46]–[48]
	ZnO nanowire	10 ~ 300 nm	Diameter	Controlled cell growth (adhesion, proliferation, differentiation) [55]–[57]
	ZnO nanowire	10 ~ 300 nm	Structure (aligned, random, vertical)
	GaP Nanowire	20 ~ 100 nm	Diameter	Controlled cell growth (adhesion, proliferation) [59]
	GaP Nanowire	20 ~ 100 nm	Diameter	Mechanosensing [58]
	Ni nanowire	10 ~ 200 nm	Diameter	Controlled cell growth (adhesion, separation, positioning) [60],[61]
			Structure (aligned, random)
			Magnetic property
	Au nanowire	3 ~ 100 nm	Diameter	Controlled cell growth (adhesion, differentiation) [63]
	Au nanowire	3 ~ 100 nm	Surface functionalization	Controlled cell growth (adhesion, differentiation) [63]
	Si nanowire	3 ~ 500 nm	Diameter	Mechanosensing [10]
			Diameter	Electrical sensor [12],[43],[44]
			Structure (aligned, random, vertical)	Intracellular delivery [42]
			Surface functionalization	Intracellular delivery [42]

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