Fig. 1From: Design, challenge, and promise of stimuli-responsive nanoantibioticsCurrent drug discovery paradigm in antibiotics. Scheme of the current paradigm in drug discovery. A target microbe that requires new antibiotics becomes the main subject of research. The discovery of new antimicrobial agents is usually discovered in soil or marine bacteria, and synthetic derivatives are generated. Based on current trends, these have up to 14 years of efficacy before resistance is developed. The resistance is usually acquired through horizontal gene transferBack to article page