From: Design, challenge, and promise of stimuli-responsive nanoantibiotics
Type | Example | Activity | Current application | References |
---|---|---|---|---|
Proteases | Pyroglutamyl-peptidase I (Staphylococcus aureus) | Cytosolic hydrolysis of terminal amino groups | Diagnosis, protein sequence analysis, antibody target | |
Lipases | PAL (Pseudomonas aeruginosa) | Hydrolysis of glycerol esters | Synthesis of industrial compounds | |
Glycosidases | EndoS (Streptococcus pyogenes) | Modulating the IgG effector functions | Immunomodulation, glycan analysis | |
Urease | UreA, UreB (Helicobacter pylori) | Conversion of urea to ammonia, neutralization of pH | Taxonomic identification, vaccine candidate | |
Glucose oxidase | GOx | Catalysis of glucose oxidation | Food processing, antibacterial, antifungal | |
Peroxidase | KatG (Mycobacterium tuberculosis) | Activates isoniazid, a frontline anti-TB drug | Proteomics, diagnostics | |
Esterase | ADP1 (Acinetobacter sp.) | Carbamate and ester cleavage | Drug abuse treatment, biocatalysis | |
Amidase | AmpD (Citrobacter freundii) | Amide cleavage, cell wall recycling | Diagnostics |