Fig. 7

Dendrimers. a Schematic 2D representation (left) of a dendrimer containing three generations (branching points) as indicated by numbers. A 3D representation (right) of dendrimer G3 showing space-filling structure. Reprinted form Ref. [111]. Copyright (2009), with permission from Elsevier. b Systemically administered dendrimer-FITC (D-FITC) localize in the injured brain. D-FITC was administered IV after 2 h hypothermic circulatory arrest (HCA) or cardiopulmonary bypass (CPB); fluorescent labeling was examined 48 h later. D-FITC labeling in the outer part of the hippocampal dentate granule cell layer (dgc) after HCA closely corresponds to the distribution of apoptotic nuclei detected with DAPI (top). Negligible labeling is observed in the hippocampus after CPB, which causes little to no injury (bottom). In cerebellum after HCA, D-FITC is prominent in many Purkinje cells (PC), which receive dense glutamatergic input and are often injured, and surrounding small hemorrhages (*). Reproduced with permission from Ref. [117]. Copyright (2014) American Chemical Society