Scheme 1
From: Deep tissue penetration of nanoparticles using pulsed-high intensity focused ultrasound
Schematic illustration of pulsed-high intensity focused ultrasound (pHIFU)-mediated tissue penetration enhancement of nanoparticles. a The pHIFU-on state allowed to heat-generation, vasodilation effect, and blood flow enhancement in the tissue, resulting in increasing vascular permeability of nanoparticles. b The vessels and blood flow in the tissue could recover, when the pHIFU was turned-off