Fig. 5
(Reprinted with permission from [87]. Copyright @ 2015 Elsevier)
Confirmation of specific cell targeting using biohybrid nanoparticles and time dependent release of Dox inside cells. a, c SERS map images of biohybrid nanoparticles added to co-cultured SH-SY5Y and SK-BR-3 cells respectively. SERS mapping images were measured at the 1275 cm−1 Raman band. b, d Bright-field images of the SH-SY5Y and SK-BR-3 cells respectively. (scale bar: 20 μm (b), and 5 μm (d)). e SERS spectra of the SK-BR-3 cells treated with Dox loaded biohybrid nanoparticles at different incubation times. f Relationship between time and release of Dox. The error bars indicate the standard deviation of ten measurements in three individual cells