a Preparation, properties, and functions of SNO-HDL mimicking NPs. b NO release from SNO-HDL mimicking NPs (red solid line) and DPPNOTE (brown solid line) at 37 °C. c, d Cholesterol efflux from 3H-cholesterol loaded J774 macrophages (c) and differentiated THP-1 macrophages (d) to SNO-HDL mimicking NPs. e Plasma creatinine levels of mouse kidney transplant recipients on day 2 post transplantation. f Quantification of apoptosis staining in kidney transplant recipients. g Quantification of immunocytochemistry staining for Gr-1, a neutrophil marker, in kidney transplant recipients. h Comparison of atherosclerotic area of ApoE−/− mice fed with a high-fat diet (HFD) for 12 weeks, then administered with PBS, HDL mimicking NPs, or SNO-HDL mimicking NPs for an additional 6 weeks. i Representative images of aortas from mice treated with PBS, HDL mimicking NPs, or SNO-HDL mimicking NPs. Red fluorescent staining indicates atherosclerotic plaques.