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Fig. 4 | Nano Convergence

Fig. 4

From: Regulation of intracellular transition metal ion level with a pH-sensitive inorganic nanocluster to improve therapeutic angiogenesis by enriching conditioned medium retrieved from human adipose derived stem cells

Fig. 4

The effect of endocellularly released iron through endocytosis. TEM image of hADSCs (a) with and (b) without ps-TNC treatment (3 µg/mL, 12 h, N: nucleus, red arrows: ps-TNCs in endosomes, Scale bars = 2 µm). Dash lined box shows the high magnification image in the left side. c Comparison of HIF-1a, hFGF and VEGF expression in untreated hADSCs, with gold nanoparticles treatment (3 µg/mL, 12 h), and ps-TNC treatment (3 µg/mL 12 h, n = 3, #p < 0.01, *p < 0.05 compared to the untreated group). d Relative amount of iron ion detected in hADSCs after ps-TNC treatment as quantified by ICP-OES (n = 5, *p < 0.01 compared to the untreated group). e The amount of iron ion detected in various media as quantified by ICP-OES (n = 4). f, g The migration of hADSCs treated with CM or ps-TNC-CM for 24 h (n = 4, #p < 0.01, ##p < 0.001 compared to 0 h of each groups)

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