Fig. 3
From: Real-time monitoring of liver fibrosis through embedded sensors in a microphysiological system
a Real-time TEER data graph presents the comparative impedance to different ECM time graphs in the liver MPS (data presented as mean ± SD). b Real-time TEER data graph illustrates the comparative impedance to the time graph of different ECM and TGF-β1 responses in the liver fibrosis-on-chip model. The TEER values increased till the formation of a monolayer at 72 h. TGF-β1 was introduced in the MPS at 72 h, which results in the drop of TEER values due to cell–cell tight junction disruption and activation of fibroblasts. Activated fibroblasts produced ECM, which eventually increased the TEER values (data presented as mean ± SD)