Fig. 4
From: Ultrasmall iron oxide nanoparticles induced ferroptosis via Beclin1/ATG5-dependent autophagy pathway
USIONPs-induced ferroptosis reversed by FER-1. a Inhibitory rates of U251 cells and C6 cells in exposure to USIONPs with or without 0.4 μmol/L FER-1 for 48 h; b Relative levels of ROS in the U251 cells and C6 cells in exposure to USIONPs with or without 0.4 μmol/L FER-1 for 48 h; c Relative levels of lipid ROS in the U251 cells and C6 cells in exposure to USIONPs with or without 0.4 μmol/L FER-1 for 48 h; d Concentrations of iron in the U251 cells and C6 cells in exposure to USIONPs with or without 0.4 μmol/L FER-1 for 48 h; E Representative images of ferroptosis related proteins in the U251 cells and C6 cells in exposure to USIONPs with or without 0.4 μmol/L FER-1 for 48 h; f Relative expression levels of proteins involved in the ferroptosis pathway in the U251 cells and C6 cells in exposure to USIONPs with or without 0.4 μmol/L FER-1 for 48 h. *P < 0.05, statistically significant compared with control group. #P < 0.05, statistically significant compared with 200 μg/mL USIONPs