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Fig.5 | Nano Convergence

Fig.5

From: Ultrasmall iron oxide nanoparticles induced ferroptosis via Beclin1/ATG5-dependent autophagy pathway

Fig.5

Effect on the USIONPs-induced ferroptosis after treatment with 200 μg/mL USIONPs, 20 μmol/L zVAD.fmk (apoptosis inhibitor), 20 μmol/L necrostatin-1 (necrosis inhibitor), 10 μmol/L VX765(pyroptosis inhibitor), and 10 μmol/L 3-MA (autophagy inhibitors) for 48 h. a Representative images of U251 cell proliferation by cell staining using Edu and Hoechst3342 (Magnification, 200 ×); b Inhibitory rates of U251 cells; c Concentrations of iron in the U251 cells; d Relative levels of lipid ROS in the U251 cells; (E)Relative levels of ROS in the U251 cells. *P < 0.05, statistically significant compared with control group

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