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Nano Convergence
Fig. 3 | Nano Convergence

Fig. 3

From: Impact of the conjugation of antibodies to the surfaces of polymer nanoparticles on the immune cell targeting abilities

Fig. 3

T cell targeting efficiency of the CD8a-conjugated NPs in vitro. A Binding of the anti-CD8a conjugated NPs to the CD8a T cells. The mouse splenocytes were treated with the NPs for 10 min after loading the NPs with DiD and assessed through flow cytometry. B Observed DiD signal in the CD4 T cells that confirms the minimal non-specific binding of the anti-CD8a conjugated NPs, and (C) Comparison between the populations of the DiD-expressing CD8 T cells induced by the full-CD8a NPs and f(ab′)2-CD8a NPs at different instants. Data were presented as the mean ± SD (n = 3, *P = 0.0332, **P = 0.0021, ***P = 0.0002, ****P < 0.0001)

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