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Nano Convergence
Fig. 4 | Nano Convergence

Fig. 4

From: PFP@PLGA/Cu12Sb4S13-mediated PTT ablates hepatocellular carcinoma by inhibiting the RAS/MAPK/MT-CO1 signaling pathway

Fig. 4

PPCu-mediated PTT ablates HCC tumor in vivo. A Thermographic images and corresponding temperature levels of tumor regions under NIR laser irradiation within 10 min. B MRI of mice with tumors before and after treatment at the 3rd day, 7th day and 14th day, the arrows indicating the location of tumors. C Photographs of excised tumors from mice with different treatments at the 14th day. D Relative volume of tumors before and after treatments. (1), (2), (3), (4), and (5) represent PBS, PFP@PLGA + NIR for 10 min, PPCu, PPCu + NIR irradiation for 5 min, and PPCu + NIR irradiation for 10 min, respectively. E Average weights of tumors at the 14th day after treatment. (1), (2), (3), (4), and (5) represent PBS, PFP@PLGA + NIR for 10 min, PPCu, PPCu + NIR irradiation for 5 min, and PPCu + NIR irradiation for 10 min, respectively. F Relative body weight of mice before and after different treatments. (1), (2), (3), (4), and (5) represent PBS, PFP@PLGA + NIR for 10 min, PPCu, PPCu + NIR irradiation for 5 min, and PPCu + NIR irradiation for 10 min, respectively. Data are presented as the mean ± SD of three independent experiments. *compared with the control, p < 0.05. ** compared with the control, p < 0.01. *** compared with the control, p < 0.001

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