Skip to main content
Nano Convergence
Fig. 8 | Nano Convergence

Fig. 8

From: PFP@PLGA/Cu12Sb4S13-mediated PTT ablates hepatocellular carcinoma by inhibiting the RAS/MAPK/MT-CO1 signaling pathway

Fig. 8

Hyperthermia induces mitochondrial dysfunction of HCC cells. A Variation in mRNA expression between the control and 50 °C groups evaluated by scatter plot. The mRNAs above the top dashed line and below the bottom dashed line indicate more than 1.5-fold change. B The volcano plot was drawn with differentially expressed genes screened by fold change values and p-values. C The cluster heat map of differentially expressed mRNAs with low or high expression level indicated by green or red, respectively. D Real-time PCR results of top five downregulated mRNAs mentioned above. The results represent three independent tests. *compared with the control, p < 0.05. ** compared with the control, p < 0.01. *** compared with the control, p < 0.001. E Expression of MT-CO1 in HepG2, HCCLM3 and Huh7 explored by western blotting and β-actin used as a control. F Western blot analysis for the critical regulator of the RAS/MAPK and RAS/PI3K/AKT signal pathways in HepG2, HCCLM3 and Huh7 cells

Back to article page