Table 4 Clinical trials utilizing nanomaterials to enhance radiation therapy
From: Cancer nanotechnology: current status and perspectives
NCT Number | Title | Conditions | Interventions | Phases |
|---|---|---|---|---|
NCT04862455 | NBTXR3, radiation therapy, and Pembrolizumab for the treatment of recurrent or metastatic head and neck squamous cell cancer | Metastatic head and neck squamous cell carcinoma/recurrent head and neck squamous cell carcinoma | Other: Hafnium oxide-containing NPs NBTXR3/Radiation: hypofractionated radiation therapy/Biological: Pembrolizumab/Radiation: stereotactic body radiation therapy | Phase 2 |
NCT04789486 | Nano-SMART: NPs With MR guided SBRT in NSCLC and pancreatic cancer | NSCLC/advanced pancreatic adenocarcinoma/unresectable pancreatic cancer/ductal adenocarcinoma of the pancreas | Drug: AGuIX/Radiation: radiotherapy | Phase 1/2 |
NCT04682847 | Radiotherapy with iron oxide NPs (SPION) on MR-Linac for primary & metastatic hepatic cancers | Liver neoplasms/hepatic cirrhosis/hepatic carcinoma/liver cancer/liver metastases/liver carcinoma/hepatocellular carcinoma/hepatocellular cancer/hepatic atrophy | Drug: Ferumoxytol injection | |
NCT04615013 | NBTXR3, chemotherapy, and radiation therapy for the treatment of esophageal cancer | Cervical Esophagus Adenocarcinoma/Clinical Stage II esophageal adenocarcinoma AJCC v8/Clinical Stage IIA esophageal adenocarcinoma AJCC v8/Clinical Stage IIB esophageal adenocarcinoma AJCC v8/Clinical Stage III esophageal adenocarcinoma AJCC v8/Gastroesophageal Junction Adenocarcinoma/Pathologic Stage II esophageal adenocarcinoma AJCC v8/Pathologic Stage IIA esophageal adenocarcinoma AJCC v8/Pathologic Stage IIB esophageal adenocarcinoma AJCC v8/Pathologic Stage III esophageal adenocarcinoma AJCC v8/Pathologic Stage IIIA esophageal adenocarcinoma AJCC v8/Pathologic Stage IIIB esophageal adenocarcinoma AJCC v8/Thoracic Esophagus Adenocarcinoma | Drug: Capecitabine/Drug: Carboplatin/Drug: Docetaxel/Drug: Fluorouracil/Other: Hafnium oxide-containing NPs NBTXR3/Radiation: intensity-modulated radiation therapy/Drug: Leucovorin/Drug: Oxaliplatin/Drug: Paclitaxel | Phase 1 |
NCT04505267 | NBTXR3 and radiation therapy for the treatment of inoperable recurrent NSCLC | Recurrent lung non-small cell carcinoma/Stage I lung cancer AJCC v8/Stage IA1 lung cancer AJCC v8/Stage IA2 lung cancer AJCC v8/Stage IA3 lung cancer AJCC v8/Stage IB lung cancer AJCC v8/Stage II lung cancer AJCC v8/Stage IIA lung cancer AJCC v8/Stage IIB lung cancer AJCC v8/Stage III lung cancer AJCC v8/Stage IIIA lung cancer AJCC v8/Stage IIIB lung cancer AJCC v8/Stage IIIC lung cancer AJCC v8/Unresectable lung non-small cell carcinoma | Other: Hafnium Oxide-containing NPs NBTXR3/Radiation: radiation therapy | Phase 1 |
NCT04484909 | NBTXR3 activated by radiation therapy for the treatment of locally advanced or borderline-resectable pancreatic cancer | Borderline resectable pancreatic adenocarcinoma/locally advanced pancreatic ductal adenocarcinoma/resectable pancreatic ductal adenocarcinoma/stage III pancreatic cancer AJCC v8 | Other: Hafnium Oxide-containing NPs NBTXR3/Radiation: radiation therapy | Phase 1 |
NCT04240639 | An extension study MRI/US fusion imaging and biopsy in combination with nanoparticle directed focal therapy for ablation of prostate tissue | Neoplasms of the Prostate | Device: AuroShell particle infusion | Not Applicable |
NCT03589339 | NBTXR3 activated by radiotherapy for patients with advanced cancers treated with an anti-PD-1 therapy | Radiotherapy/immunotherapy/microsatellite instability-high solid malignant tumour/metastasis from malignant tumor of stomach (disorder)/squamous cell carcinoma of head and neck/metastasis from malignant tumor of cervix/metastatic squamous cell carcinoma/metastasis from malignant melanoma of skin (disorder)/merkel cell carcinoma (disorder)/metastasis from malignant tumor of lung/metastasis from malignant tumor of bladder (disorder) | Drug: NBTXR3 | Phase 1 |
NCT02379845 | NBTXR3 crystalline NPs and radiation therapy in treating randomized patients in two arms with soft tissue sarcoma of the extremity and trunk wall | Adult soft tissue sarcoma | Device: NBTXR3/Device: Radiation therapy | Phase 2/Phase 3 |
NCT01946867 | NBTXR3 and radiation therapy in treating patients with locally advanced scc of the oral cavity or oropharynx | Head and neck cancer | Device: NBTXR3 activated by IMRT | Phase 1 |