Fig. 4

Study the biocompatibility and toxicity of DE-ZnO composites in vivo. A Body weight and major organs weight changes of the mice treated with LD-DE-ZnO or HD-DE-ZnO composites by oral administration, monitored for 14 days. male and female mice after 14 days of oral administration with DE-ZnO composites. B Liver morphology changes in the mice after 14 days of oral administration with DE-ZnO. C Biochemical parameters changes in mice treated with LD-DE-ZnO or HD-DE-ZnO composites by oral administration. C Histology analysis of liver tissue of mice treated with LD-DE-ZnO or HD-DE-ZnO composites by oral administration. D The sections were stained with hematoxylin and eosin (Magnification ×200). Histologic changes showed no differences among groups (n = 4 mice per group). Each data value is mean ± SE. (n = 4 mice per group). ALT: alanine aminotransferase; AST: aspartate aminotransferase; T-Bil: total bilirubin; BUN: blood urea nitrogen; TP: total protein; A/G: albumin/globulin; TC: total cholesterol; LD: low dosage; HD: high dosage