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Fig.12 | Nano Convergence

Fig.12

From: Gas-stabilizing nanoparticles for ultrasound imaging and therapy of cancer

Fig.12

Adapted from reference [48], Copyright 2014, John Wiley and Sons

a TEM images of MSNs (i), hydrophobically modified MSNs (ii), and β-CD stabilized hydrophobic MSNs (iii). Schematic showing the molecular structure of hydrophobically modified MSN pore walls and β-CD (iv). Fluorescence assay showing in vitro ROS generation by MSNs after ultrasound exposure (v). b In vivo sonodynamic therapy using β-CD stabilized hydrophobic MSNs in ZR75-30 tumor model in mice. Relative tumor volumes of mice untreated or treated with ultrasound in the presence of nanoparticles at different concentrations (i). Photographs (ii) and H&E staining (iii) of tumors at end of the experiment.

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