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Fig. 12 | Nano Convergence

Fig. 12

From: Quantifying and controlling bond multivalency for advanced nanoparticle targeting to cells

Fig. 12

A Two ligating units (LU1 and LU2) that comprise component D can bind to receptor R at sites 1 and 2. B Graph of [D]1/2, or free receptors, vs root mean squared (RMS) linker length (r) between the two ligating units. An asymmetry in the curve is observed, with a minima around 40 Å, followed by a subsequent slow increase with RMS linker length. Below 40 Å, decreasing RMS linker length causes [D]1/2 to increase rapidly. This confirms that a linker length larger than the minima of 40 Å would tend to reduce the concentration of free receptors, increasing the concentration of bound ligating units, increasing avidity. From reference [70]

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