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Fig. 3 | Nano Convergence

Fig. 3

From: Protein nanoparticles directed cancer imaging and therapy

Fig. 3

An example of designing and preparing protein nanoparticles by self-assembly. Six amino acids were mutated to HHHHHH (His6) located in the DE loop of ferritin proteins. The resultant subunits were natural ferritin tetramers at pH 7.5. Such tetramers could self-assemble into reconstituted nanocages at pH 10.0 or by the induction of transition metal ions at pH 7.5. Conversely, the nanocages would be disassembled into ferritin tetramers by the stimuli of pH or EDTA [112]

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