Fig. 4
From: Protein nanoparticles directed cancer imaging and therapy
Schematic diagram of the synthesis, dual-model imaging, and combination therapy of multifunctional platform SMID. Upper: The silk fibroin (SF) is extracted from the silkworm cocoon and self-assembles into SF nanoparticles. The surface of SF nanoparticles is biomineralized by MnO2 (SF@MnO2). ICG and DOX are both loaded onto SF@MnO2 (SMID); Bottom: After intravenous injection, the tumor sites of mice are irradiated with a near-infrared (NIR) laser. The Mn2+ is produced under an acidic microenvironment, and ICG makes SMID an appropriate contrast agent for MR/fluorescence imaging. DOX and ICG is used for chemotherapy and photodynamic/photothermal therapy, respectively [166]