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Table 2 Comparison of advantages and disadvantages of common synthesis methods of protein nanoparticles

From: Protein nanoparticles directed cancer imaging and therapy

Preparation strategy

Advantages

Disadvantages

Key factors

Desolvation

Mild conditions, without surfactants, and simple process [72]

Unstable particle size [34]

pH [72]

Emulsification

Uniform size [99]

Necessary surfactants, complex preparation process [96, 97]

Monodisperse droplets [99]

Salting out

Simple and green preparation [67]

Wide size distribution [102]

pH [102]

Spray drying

Good particle dispersion, convenient operation and control, and suitable for mass production [104, 106]

Equipment support required [107]

Surfactant concentrations and spray mesh sizes [107]

Self-assembly

Reversible [110]

Limited scope of application

pH [112]