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Fig. 3 | Nano Convergence

Fig. 3

From: Bioenzyme-based nanomedicines for enhanced cancer therapy

Fig. 3

Reproduced with permission from [45]. Copyright 2020, Wiley–VCH

a Schematic illustration of the fabrication of collagenase-based nanoscavengers and their size increase and dissociation of the collagenase containing components in response to the acidic pH. b Schematic illustration of the increased penetration and retention of nanoparticles in deep tumor tissues via the combined action of collagenase digestion of collagen fibers and particle size increase, and the destruction of mitochondrial DNA via mitochondria-specific targeting and release of cisplatin drugs into mitochondria.

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