Bioenzyme-based nanomedicines for enhanced cancer therapy

Ding, Mengbin; Zhang, Yijing; Li, Jingchao; Pu, Kanyi

doi:10.1186/s40580-022-00297-8

Nano Convergence

Table 1 Summary of bioenzyme-based nanomedicines for enhanced cancer therapy

From: Bioenzyme-based nanomedicines for enhanced cancer therapy

Therapeutic modality	Nanosystem	Enzyme	Work mechanism	Reference
Chemotherapy	Nanogels	Ribonuclease A	Catalyze RNA degradation	[36]
	Mesoporous silica	Ribonuclease A	Catalyze RNA degradation	[37]
	Large-pore mesoporous silica	Ribonuclease A	Degrade mRNA and tRNA	[38]
	Polymer-based nanoparticles	Ribonuclease A	Degrade cellular RNA	[39]
	Hollow organosilica	Glucose oxidase	Consume glucose	[40]
	Mesoporous polydopamine	Glucose oxidase	Consume glucose	[41]
	Liposomes	Glucose oxidase	Consume glucose	[42]
	Porous silica nanoparticles	Hyaluronidase	Decompose HA-DOX to produce toxic dissociative DOX	[43]
	Micelles	Collagenase	Digest collagen fibers in tumor ECM	[45]
	Nanogels	Collagenase	Digest tumor ECM	[46]
	Heavy-chain ferritin nanocages	Collagenase	Degrade the collagen in tumor ECM	[47]
	PCL-PEG nanoparticles	Collagenase IV	Degrade the collagen component of ECM	[48]
	Chitosan nanoparticles	Bromelain	Digest tumor ECM	[49]
	Hierarchical nanoparticles	Hyaluronidase	Degrade hyaluronic acid in tumor ECM	[51]
	Micelles	Hyaluronidase	Degrade hyaluronic acid in tumor ECM	[52]
PTT	Ultrasmall platinum nanoparticles	Glucose oxidase	Catalyze glucose to produce H₂O₂ and D-glucono-δ-lactone	[58]
	Semiconducting polymer nanoparticles	Bromelain	Digest collagen in tumor ECM	[59]
	Gold/mesoporous polydopamine nanoparticles	Papain	Degrade tumor ECM	[60]
	Liquid metal nanoparticles	Glucose oxidase	Inhibit ATP and HSP levels	[61]
	Porous hollow Prussian blue nanoparticles	Glucose oxidase	Enhance glucose depletion	[62]
	Hollow mesoporous silica	Glucose oxidase	Reduce the thermo-resistance and consume glucose	[63]
	Gold nanoparticles	Myrosinase	convert nontoxic GRE into toxic SFE	[35]
	Liposomes	Glucose oxidase	Consume glucose and inhibit HSP expression	[64]
PDT	Hyaluronic-acid-based nanoparticles	Catalase	Decompose endogenous H₂O₂ to generate O₂	[69]
	Polymeric micelles	Catalase	Catalyze endogenous H₂O₂ to generate O₂	[70]
	Upconversion nanoparticles	Catalase	Catalyze endogenous H₂O₂ to generate O₂	[71]
	Mesoporous silica	Glucose oxidase	Catalyze glucose consumption to generates H₂O₂	[72]
	Biomimetic hybrid nanozymes	Glucose oxidase	Oxidize glucose to gluconic acid and H₂O₂	[73]
	Manganese-doped calcium phosphate nanoparticles	Catalase and glucose oxidase	Convert intracellular H₂O₂ to O₂ and intratumoral glucose to H₂O₂ and gluconic acid	[75]
	Metal–organic frameworks	Catalase and glucose oxidase	Convert intracellular H₂O₂ to O₂ and consume glucose	[76]
	Semiconducting polymer nanoparticles	Ribonuclease A	Degrade intracellular RNA	[77]
CDT	Metal organic frameworks	Glucose oxidase	Catalyze glucose oxidation to produce H₂O₂ and gluconic acid	[80]
	Iridium oxide nanoparticles	Glucose oxidase	Oxidize glucose to gluconic acid and H₂O₂	[81]
	Nanogels	Lactate oxidase and catalase	Catalyze lactate to produce H₂O₂ and decompose H₂O₂ into O₂	[82]
	Zeolitic imidazole framework	Catalase and DNAzyme	Silence CAT and deplete GSH	[83]
RT	TaOx nanoparticles Cisplatin-prodrug-based liposomes	Catalase Catalase	Degrade H₂O₂ to generate O₂ Degrade H₂O₂ to generate O₂	[86] [87]
Immunotherapy	γ-PGA nanoparticles	Glucose oxidase	Deplete glucose	[92]
	Tetraethyl orthosilicate	Catalase	Degrade H₂O₂ to generate O₂	[93]
	PLGA nanoparticles	Catalase	Degrade H₂O₂ to generate O₂	[94]
	Dextran-conjugated nanoparticles	Hyaluronidase	Degrade hyaluronic acid in tumor CEM	[95]
	Microneedles	Hyaluronidase	Degrade hyaluronic acid in tumor CEM	[97]
	Semiconducting polymer nanoparticles	Kynureninase	Degrade the immunosuppressive kynurenine	[99]

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