Fig. 4
From: Nanotechnology-enabled immunoengineering approaches to advance therapeutic applications
Reproduced with permission from ref [81]
Surface engineering of T cells with nanoparticles. a Schematic diagram depicting the liposomes anchoring to either CD45 or Thy1.1 receptor on T cells. b Flow cytometry showed that remaining liposomes on cell surface-bound to CD45, a non-internalizing receptor, were significantly greater than those bound to Thy1.1, an internalizing receptor. c T cells loaded with anti-CD45 liposomes containing TGF-β inhibitors led to greater infiltration in tumors. d CD45 bound liposomes decreased the tumor size of B16F10 tumors compared to either free or Thy1.1 bound liposomes.