Nanotechnology-enabled immunoengineering approaches to advance therapeutic applications

Chuang, Skylar T.; Conklin, Brandon; Stein, Joshua B.; Pan, George; Lee, Ki-Bum

doi:10.1186/s40580-022-00310-0

Nano Convergence

Table 1 Surface engineering of immune cells with nanomaterials for delivery

From: Nanotechnology-enabled immunoengineering approaches to advance therapeutic applications

Cell Source	Cargo	Size	Functionalization Strategy	Application	References
T cell	Multilamellar liposomes	~ 300 nm	Maleimide-cell surface thiol	B16F10 melanoma lung and bone marrow tumors	[79]
	Lipid-coated PLGA	~ 230 nm	Maleimide-cell surface thiol	B16F10 melanoma lung and bone marrow tumors	[79]
	Liposomes	~ 200 nm	Maleimide-cell surface thiol	Prostate tumor	[80]
	Lipid nanocapsules	~ 340 nm	Maleimide-cell surface thiol	Lymphoma cells	[83]
	Liposomes	~ 83 nm	CD45 antibody conjugation	B16F10 melanoma	[81]
	Cytokine nanogels	~ 100 nm	Covalent conjugation via crosslinker/ electrostatic interaction	B16F10 melanoma	[82]
	Lipid nanocapsules	~ 240 nm*	Maleimide-cell surface thiol	Functional modification of CTLs	[84]
CAR T-cell	Cytokine nanogels	~ 80–130 nm	CD45 antibody conjugation/ electrostatic interaction	B16F10 melanoma	[78]
CAR T-cell	Multilamellar liposomes	~ 160 nm*	Maleimid-cell surface thiol	SKOV 3 ovarian cancer and leukemia	[85]
NK cell	Liposomes	~ 138 nm	NK1.1 antibody conjugation	SW620 colon cancer cells	[86]
NK cell	Graphene oxide-PEG nanoclusters	~ 50–300 nm	CD16 antibody conjugation	Activation of NK cells	[87]
CAR NK- cell	Liposomes	~ 220 nm*	Maleimide-cell surface thiol	SKOV 3 Ovarian cancer	[88]
Leukocyte	Liposomes	~ 118 nm	Binding between E-selectin receptor and apoptosis inducing ligand TRAIL	Circulating colon cancer cells (COLO 205)	[89]
B cell	Multilamellar Liposomes	~ 300 nm	Maleimide-cell surface thiol	B16F10 melanoma lung and bone marrow tumors	[79]
HSC	Multilamellar Liposomes	~ 300 nm	Maleimide-cell surface thiol	B16F10 melanoma lung and bone marrow tumors	[79]

*Size values taken from previously reported literature sources [90, 91]

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