Fig. 10

a Synthesis of the P(CPT-MAA) prodrug nanogels, b Schematic illustration of the pH and redox dual responsive drug release of P(CPT-MAA) prodrug nanogels, c The redox-responsive drug release mechanism, d The pH-responsive mechanism (Panel A). In vivo antitumor assays. a Relative tumor volume and b body weight of the Hep G2 tumor-bearing BALB/c nude mice administrated by the intravenous injection of PBS, blank PMAA nanogels, free CPT (5 mg CPT/kg), P(CPT-MAA) nanogels without single bond (5 mg CPT/kg), and P(CPT-MAA) prodrug nanogels (5 mg CPT/kg and 10 mg CPT/kg), respectively. c Photo images of the harvested tumors at 21 days post the first injection, no tumor of free CPT group obtained due to the death of all mice at 13 days. *, p < 0.05; **, p < 0.01, compared with PBS, Blank PMAA groups (Panel B). Reprinted with permission from Journal of Controlled Release,