Fig. 3
From: Smart nanomaterials for cancer diagnosis and treatment
Schematic illustration of the DHP structure and multiple theranostic applications. Therapeutic efficacy of DHP (Panel A). Chemo-photothermal cytotoxicity of DHP on 4T1 tumor cells, determined by the live/dead assay. The scale bars are 200 μm and applied for all images (Panel B). Tumor volume and excised tumor weight of 4T1 tumor-bearing BALB/c mice after different treatments. Black arrows represent i.v. administration of various formulations, while red arrows represent laser irradiation (Panel C). H&E staining, ki67 immunohistochemistry, and TUNEL fluorescence staining of tumor sections at the end of the in vivo antitumor experiment. The scale bars are 100 μm and applied for all images (Panel D). Data in B and C represent mean ± SEM n = 5; *p < 0.05; **p < 0.01; ***p < 0.001. Reprinted with permission from Nanoletters, Copyright 2019, American Chemical Society [74].