Fig. 4
From: Smart nanomaterials for cancer diagnosis and treatment
Copyright 2019, John Wiley and Sons [81]
a PA images of the mouse tumor at different times after injection of IONPs-ICG-HA. b Fluorescence signals of IONPs-ICG-HA in tumor and major tissues (n = 3, mean – SD). c Ex vivo fluorescence images of IONPs-ICG-HA injected mice. d Infrared thermal images of mice 6 h post injection of saline or IONPs-ICG-HA under different irradiation time (Panel A). a Body weight changes of nude mice during treatment (n = 5, mean SD). b Tumor growth curves during treatment (n = 5, mean **P < 0.01, ***P < 0.001. c Digital photos of tumors after PDT/PTT synergistic therapy. d Histological microscopy images of tumors after treatments: 1) control, 2) ICG, 3) IONPs, and 4) IONPs-ICG-HA. (Scale bar: 50 μm) (Panel B). Reprinted with permission from Small,