Fig. 15

a Schematic of the activation mechanism of Proc-4-OHT through the Pd-catalyzed propargyl uncaging reaction. Drug activation stabilized the GFP-labeled protein ER50 in breast cancer cells. b, c Fluorescence imaging and flow cytometric analysis of ER50-GFP-transfected HeLa cells confirm the protein stabilization upon incubation with the nanozyme and prodrug. Reprinted from Ref. [215] with permission from the American Chemical Society. Copyright 2022