Fig. 16

a Schematic of the nanozyme-catalyzed activation of a fluorophore Rhodamine 110 and anticancer drug 5-FU and structure of the Au NP ligand. b Illustration of nanozyme uptake in macrophages (RAW 254.7) and co-culture assay with HeLa cells. c, d Comparable efficiency of the HeLa cells and macrophages after the bioorthogonal activation of 5-FU with that of the prodrug approach. Reprinted from Ref. [194] with permission from the American Chemical Society. Copyright 2022