Fig. 17
From: Biomimetic and bioorthogonal nanozymes for biomedical applications
a Schematic of the preparation of the nanozyme and bioorthogonal release of Vorinostat in tumor to initiate macrophage repolarization. b Mannose-functionalized nanozymes are uptaken by cancer cells and mediate the uncaging of propargyl-protected Vorinostat (Pro-V). c Similar levels of Arg I and IL-10 and considerably increased levels of iNOS and TNF-α in the phenotype markers of the treated macrophages compared to that of the free drug. d Improvement of treatment efficiency based on tumor volume after treatment with the nanozyme and prodrug relative to those of the free drug and controls. e Body weight of mice during treatment. f Staining of tumors with hematoxylin and eosin (H&E) to observe the changes in tumor tissue after treatment. Reprinted from Ref. [195] with permission from Elsevier Inc. Copyright 2022