Fig. 20

a Schematic of the nanozyme fabrication process. b Intracellular activation of ibuprofen mediated by the chiral nanozymes. c H&E staining of mouse paws treated with the (1) saline, (2) LPS, (3) LPS and the CD-nanozyme, and (4) LPS, CD-nanozyme, and prodrug. Inflammation-inducing conditions caused extensive morphological damage of the tissue. CD-nanozyme and prodrug reduced inflammation and preserved the morphology of the healthy tissue. d) ROS imaging of untreated, treated, and control mouse paws. e ROS reduction quantified through fluorescence measurement of the ROS-responsive dye, DCFH-DA. f PGE₂ levels of the respective treatment groups and controls. Reprinted from Ref. [183] with permission from Elsevier Inc. Copyright 2022