Fig. 22

a Nanozyme structure and schematic of the encapsulation of the Ru-based TMC. After nanoparticle degradation, the release of ligands increases the catalytic rate due to the presence of nucleophiles. b Comparison between the catalytic performance of Au and ZnS nanozymes. c Rate-determining step of catalysis involves the conjugation of a nucleophile to the cleaved residue. d Uncaging reaction of the propargyl-protected anticancer drug mitoxantrone. e Higher cell killing efficiency of ZnS nanozyme than that of Au nanozyme after the prodrug activation. Reprinted from Ref. [198] with permission from the American Chemical Society. Copyright 2022