Fig. 26

a Schematic of the nanozyme fabrication and enhancement of combination drug release using a near IR laser. b Pd-catalyzed propargyl uncaging of a coumarin derivative and Cu-mediated azide–alkyne "click" reaction of a coumarin triazole species. c Independent confocal imaging of both fluorophores, demonstrating the enhanced Pd activity upon near IR irradiation. d Concurrent intracellular release of anticancer drugs. e Body weight of 4T1 tumor-bearing mice in different treatment groups: (1) PSB control and 808 nm light, (2) nanozyme and 808 nm light, (3) PBS control and 1064 nm light, (4) nanozyme and 1064 nm light, (5) nanozyme, prodrugs, and 808 nm light, (6) nanozyme, prodrugs, and 1064 nm light. f Changes in tumor volume for the same treatment groups as described in e), demonstrating the considerably decreased tumor growth upon treatment with nanozyme, prodrugs, and 1064 nm light. g Temperature changes in the tumors of 4T1 tumor-bearing mice as a function of the irradiation time. Reprinted from Ref. [202] with permission from the American Chemical Society. Copyright 2022