Table 1 TMCs and nano scaffolds used to fabricate nanozymes with their respective bioorthogonal reaction

Pd(0), Pd(II)

PLGA-PEG NPs, AuNPs, MoS₂ nanosheets, ZrO₂ MOFs

Propargyl uncaging

[191,192,193,194,195]

Polystyrene NPs, macroporous silica

Suzuki–Miyaura coupling

[196, 197]

Large pore silica

Transfer Hydrogenation

[183]

Ru

AuNPs, ZnS NPs, Single Chain NPs

Allyl carbamate uncaging

[22, 198, 199]

Cu(I), Cu(II)

Single Chain NPs, CuAl-LDH nanosheets

Azide–alkyne cycloaddition

[200, 201]

CuS Polydopamine NPs, PdCu NPs

Click reaction, propargyl uncaging

[202, 203]

Fe(III)

Polymeric Nanoparticles (PONI-C₁₁-TMA), AuNPs

Azide uncaging reaction

[184, 204, 205]

Au(I), Au(III)

Polymeric Nanoparticles (PONI-C₁₁-TMA)

Intramolecular Cyclization

[189]

Resin NPs

Propargyl Uncaging

[206]