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Fig. 5 | Nano Convergence

Fig. 5

From: Upconverting-photon quenching-mediated perforation influx as an intracellular delivery method using posAuNP@UCNPs nanocomposites for osteoarthritis treatment

Fig. 5

Comparison of UCPPin efficiency of posAuNP@UCNPs under different IR conditions in C28/I2 cell suspensions and spheroids. A UCPPin efficiency under continuous and pulsed IR analyzed in suspended cells. The percentage of Calc + cells indicate successful UCPPin, PI + cells indicate dead cells, and Calc + /PI + cells indicates that UCPPin occurred but the cells were damaged. B UCPPin efficiency under pulsed IR at different pulse intervals (PI) analyzed in suspended cells. The pulse width (PW) and pulse number (PN) were fixed at 10 min and 2, respectively. C Comparison of UCPPin efficiency between posAuNP@UCNPs 1:0 and 1:5 analyzed in spheroids under pulsed IR. Scale bar, 100 μm

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