Fig. 5
From: Biomolecular engineering for nanobio/bionanotechnology
(Figure reproduced with permission from: Ref. [62]. Copyright (2016) with permission from John Wiley and Sons)
Light-induced cellular uptake of Tf or a chemotherapeutic drug through degradation of P-Aggs. a–c Confocal microscopy images of DLD1 cells treated with P-Aggs consisting of SA and AF647-labeled caged Tf before light irradiation. d–f Those after light irradiation at 8 J cm−2. a, d AF647-fluorescence images, b, e differential interference contrast (DIC) images, c, f each merged image of (a, b) or (d, e), respectively. The scale bars are 50 μm. g Cell viabilities of the DLD1 cells treated with doxorubicin-modified Tf (Tf-DOX) or with P-Aggs consisting of SA and the caged Tf-DOX before and after light irradiation at 8 J cm−2